Invention Grant
- Patent Title: Compounds with medicinal effects due to interaction with the glucocorticoid receptor
- Patent Title (中): 与糖皮质激素受体相互作用具有药效的化合物
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Application No.: US11641524Application Date: 2006-12-19
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Publication No.: US07960365B2Publication Date: 2011-06-14
- Inventor: Niall Morton Hamilton , Simon James Anthony Grove , Michael John Kiczun , John Richard Morphy , Brad Sherborne , Peter Thomas Albert Littlewood , Angus Richard Brown , Celia Kingsbury , Michael Ohhlmeyer , Koc-Kan Ho , Steven G. Kultgen
- Applicant: Niall Morton Hamilton , Simon James Anthony Grove , Michael John Kiczun , John Richard Morphy , Brad Sherborne , Peter Thomas Albert Littlewood , Angus Richard Brown , Celia Kingsbury , Michael Ohhlmeyer , Koc-Kan Ho , Steven G. Kultgen
- Applicant Address: NL Oss
- Assignee: N.V. Organon
- Current Assignee: N.V. Organon
- Current Assignee Address: NL Oss
- Agent Susan L. Hess; Gerard M. Devlin
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A01N57/00

Abstract:
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.
Public/Granted literature
- US20070149577A1 Compounds with medicinal effects due to interaction with the glucocorticoid receptor Public/Granted day:2007-06-28
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