Invention Grant
US07960383B2 Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors
失效
哒嗪-3（2H） - 酮衍生物及其用作PDE4抑制剂
- Patent Title: Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors
- Patent Title (中): 哒嗪-3（2H） - 酮衍生物及其用作PDE4抑制剂
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Application No.: US11629522Application Date: 2005-06-13
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Publication No.: US07960383B2Publication Date: 2011-06-14
- Inventor: Antonia Maria Buil Albero , Vittorio Dal Piaz , Yolanda Garrido Rubio , Jordi Gracia Ferrer , Lluis Miquel Pages Santacana , Joan Taltavull Moll
- Applicant: Antonia Maria Buil Albero , Vittorio Dal Piaz , Yolanda Garrido Rubio , Jordi Gracia Ferrer , Lluis Miquel Pages Santacana , Joan Taltavull Moll
- Applicant Address: ES Barcelona
- Assignee: Laboratorios Almirall SA
- Current Assignee: Laboratorios Almirall SA
- Current Assignee Address: ES Barcelona
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Priority: ES200401500 20040618
- International Application: PCT/EP2005/006304 WO 20050613
- International Announcement: WO2005/123692 WO 20051229
- Main IPC: C07D401/12
- IPC: C07D401/12 ; A61K31/501 ; A61P29/00 ; A61P11/06 ; A61P19/02 ; A61P17/00 ; A61P17/06
Abstract:
The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention or suppression of pathological conditions, diseases and disorders known to be susceptible of being improved by inhibition of PDE4 such as asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable bowel disease.
Public/Granted literature
- US20080280918A1 Pyridazin-3(2H)-One Derivatives and Their Use as Pde4 Inhibitors Public/Granted day:2008-11-13
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