Invention Grant
US07960400B2 Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
有权
具有细胞抑制和/或细胞毒活性的三环化合物及其使用方法
- Patent Title: Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
- Patent Title (中): 具有细胞抑制和/或细胞毒活性的三环化合物及其使用方法
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Application No.: US11845143Application Date: 2007-08-27
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Publication No.: US07960400B2Publication Date: 2011-06-14
- Inventor: Aleem Gangjee
- Applicant: Aleem Gangjee
- Applicant Address: US PA Pittsburgh
- Assignee: Duquesne University of the Holy Ghost
- Current Assignee: Duquesne University of the Holy Ghost
- Current Assignee Address: US PA Pittsburgh
- Agency: Buchanan Ingersoll & Rooney PC
- Agent Craig G. Cochenour
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D471/00 ; C07D487/00 ; C07D239/70 ; C07D491/00
Abstract:
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.
Public/Granted literature
- US20090062318A1 TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF Public/Granted day:2009-03-05
Information query
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