Invention Grant
- Patent Title: Anti-cancer agents and androgen inhibition activity compound
- Patent Title (中): 抗癌剂和雄激素抑制活性化合物
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Application No.: US12519233Application Date: 2007-12-14
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Publication No.: US07960435B2Publication Date: 2011-06-14
- Inventor: Vincent C. O. Njar , Puranik Purushottamachar
- Applicant: Vincent C. O. Njar , Puranik Purushottamachar
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- International Application: PCT/US2007/087631 WO 20071214
- International Announcement: WO2008/076918 WO 20080626
- Main IPC: A61K31/18
- IPC: A61K31/18
Abstract:
A qualitative 3D pharmacophore model (a common feature based model or Catalyst HipHop algorithm) developed from well-known natural product androgen receptor down-regulating agents (ARDAs). The 3D pharmacophore model is used as a template in virtual screening compounds for new ARDAs. ARDA compounds and compounds that strongly inhibit the growth of human prostate LNCaP cells. The compounds may be used in compositions and methods of inhibiting cell proliferation of a cancer and methods of preventing or treating cancer, including prostate cancer.
Public/Granted literature
- US20100113600A1 ANTI-CANCER AGENTS AND ANDROGEN INHIBITION ACTIVITY COMPOUND Public/Granted day:2010-05-06
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