Invention Grant
US07960535B2 Recombinant lipidated PsaA protein, methods of preparation and use
失效
重组脂质化PsaA蛋白，制备和使用方法
- Patent Title: Recombinant lipidated PsaA protein, methods of preparation and use
- Patent Title (中): 重组脂质化PsaA蛋白，制备和使用方法
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Application No.: US12619357Application Date: 2009-11-16
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Publication No.: US07960535B2Publication Date: 2011-06-14
- Inventor: Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
- Applicant: Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K49/00
Abstract:
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
Public/Granted literature
- US20100260802A1 RECOMBINANT LIPIDATED PsaA PROTEIN, METHODS OF PREPARATION AND USE Public/Granted day:2010-10-14
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