Invention Grant
US07960540B2 Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
有权
富含G的寡核苷酸的抗增殖活性和使用其与核仁素结合的方法
- Patent Title: Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
- Patent Title (中): 富含G的寡核苷酸的抗增殖活性和使用其与核仁素结合的方法
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Application No.: US11982427Application Date: 2007-10-31
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Publication No.: US07960540B2Publication Date: 2011-06-14
- Inventor: John O. Trent , Paula J. Bates , Donald M. Miller
- Applicant: John O. Trent , Paula J. Bates , Donald M. Miller
- Applicant Address: US KY Louisville
- Assignee: Advanced Cancer Therapeutics, LLC
- Current Assignee: Advanced Cancer Therapeutics, LLC
- Current Assignee Address: US KY Louisville
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02
Abstract:
Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.
Public/Granted literature
- US20080318888A1 Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin Public/Granted day:2008-12-25
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