Invention Grant
- Patent Title: Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators
- Patent Title (中): 苄基环烷基鞘氨醇1-磷酸受体调节剂
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Application No.: US12748981Application Date: 2010-03-29
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Publication No.: US07960588B2Publication Date: 2011-06-14
- Inventor: Kevin R. Lynch , Timothy L. Macdonald
- Applicant: Kevin R. Lynch , Timothy L. Macdonald
- Applicant Address: US VA Charlottesville
- Assignee: University of Virginia Patent Foundation
- Current Assignee: University of Virginia Patent Foundation
- Current Assignee Address: US VA Charlottesville
- Agent Rodney L. Sparks
- Main IPC: C07C215/00
- IPC: C07C215/00 ; C07C229/00 ; C07F9/00 ; C07D333/00 ; C07D307/00 ; C07D417/00 ; C07D261/00 ; C07D231/00 ; C07D295/00 ; C07D207/00 ; A61K31/66 ; A61K31/425 ; A61K31/42 ; A61K31/415 ; A61K31/40 ; A61K31/38 ; A61K31/34
Abstract:
Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.
Public/Granted literature
- US20100249074A1 BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS Public/Granted day:2010-09-30
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