Methods and apparatuses for determining scrambling codes for minimizing co-channel interference in a communication system. A method in accordance with the present invention comprises defining at least one initial default sequence, generating a scrambling code, scrambling a signal using the generated scrambling code, comparing the scrambled signal with all other scrambled signals meeting a specified criterion, and saving the scrambling code word if the comparison determines that the signal scrambled with the scrambling code also meets the specified criterion. The scrambling codes can be compared with each other for cross-correlation purposes to determine whether they meet the specified criterion based on laboratory testing.