The present invention relates to a radio with a key and knob combination. To solve problems such as inconvenience caused by the independent PTT key and volume control knob on the traditional radios, the present invention provides a radio with a key and knob combination, comprising a PPT key unit and a volume control unit, wherein the key is installed inside a central cavity of the knob, which is a hollow knob, to form the key and knob combination. Rotation of the knob (106) may drive the shaft (102) and the toggle piece (111) to rotate synchronously, and then toggle the volume switch (112), while the pressed key (101) may cause the shaft (102) moving axially to toggle the PTT switch (103). When operating the radio with a single hand, users can both press the PTT key to initiate a call and rotate the knob to adjust the volume level by a thumb or a forefinger, and the operation is very convenient. Additionally, only an axle hole is required on the radio housing, thus the key and knob combination enhances the structural reliability of the radio.