Systems and methods for aligning a tool positioned on a moveable arm with a location or an object of interest on a body surface. Some methods comprise using one or more cameras and identifying position offsets of the location or the object of interest from the one or more cameras. Some methods comprise using at least two cameras and rectifying the images from the first and the second cameras. A variety of different tools and assemblies may be located on the moveable arm for performing various diagnostic and therapeutic procedures that take advantage of the ability of the moveable arm to rapidly and precisely position the respective tool or assembly at desired locations on a skin.