A system, method and program product for transferring structured and unstructured data in a service oriented architecture (SOA) infrastructure. A method is disclosed that includes: receiving a request for a synchronization at a service orchestration engine (SOE), wherein the synchronization includes a transfer of structured meta-data from a first node to a second node and a transfer of unstructured file data from a first file node to a second file node; creating an entry in a routing table to track the synchronization; receiving the structured meta-data at the SOE from the first node and transferring the structured meta-data to the second node; and orchestrating a peer-to-peer data transfer from the first file node to the second file node, including communicating with file handling agents at the first and second file handling nodes.