Systems and methods for processing message subscriptions using pre-compiled code-blocks for expression evaluation. In one embodiment, a system is configured find a set of unique clauses in a set of expressions representing message subscriptions, express the expressions as Boolean functions of the unique clauses, and compile the Boolean functions into a set of assembly instructions for efficient expression evaluation. In another embodiment, a system is configured to receive a message, generate a set of True/False assignments to a set of clauses in a set of expressions, and evaluate the expressions using an efficient compiled expression evaluation code-block.