Invention Grant
- Patent Title: Monomethylvaline compounds capable of conjugation to ligands
- Patent Title (中): 能与配体结合的单甲基缬氨酸化合物
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Application No.: US11833959Application Date: 2007-08-03
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Publication No.: US07964566B2Publication Date: 2011-06-21
- Inventor: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
- Applicant: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
- Applicant Address: US WA Bothell
- Assignee: Seattle Genetics, Inc.
- Current Assignee: Seattle Genetics, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/02 ; C07K2/00
Abstract:
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
Public/Granted literature
- US20080248053A1 MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS Public/Granted day:2008-10-09
Information query
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