Invention Grant
- Patent Title: Process for producing optically active theaspirane
- Patent Title (中): 光学活性硅烷的制备方法
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Application No.: US11992067Application Date: 2006-09-08
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Publication No.: US07964637B2Publication Date: 2011-06-21
- Inventor: Makoto Harada , Hiroyuki Matsuda , Kenya Ishida , Yuichiro Yamazaki
- Applicant: Makoto Harada , Hiroyuki Matsuda , Kenya Ishida , Yuichiro Yamazaki
- Applicant Address: JP Tokyo
- Assignee: Takasago International Corporation
- Current Assignee: Takasago International Corporation
- Current Assignee Address: JP Tokyo
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent Peter F. Corless; Christine C. O'Day
- Priority: JP2005-264678 20050913
- International Application: PCT/JP2006/317876 WO 20060908
- International Announcement: WO2007/032279 WO 20070322
- Main IPC: A61K31/335
- IPC: A61K31/335 ; C07D307/94
Abstract:
A simplified production method of stereoisomer of theaspiran having high optical purity has been desired. An alcohol compound having a specific skeleton is enantioselectively esterified with an enzyme, or an ester compound having a specific skeleton is enantioselectively hydrolyzed with an enzyme. The resultant optically active ester or optically active alcohol is used. Thus, optically active theaspiran having a desired configuration and having a high optical purity is obtained in a satisfactory yield.
Public/Granted literature
- US20090270516A1 Process for Producing Optically Active Theaspirane Public/Granted day:2009-10-29
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