Invention Grant
US07964723B2 And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
有权
专门生产（S）-9-氟-3-甲基-10-（4-甲基-1-哌嗪基）-7-氧代-2,3-二氢-7H-吡啶并[1,2,3 ，de] [1,4]苯并恶嗪-6-羧酸半水合物
![And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate](/docs/US/2011-06-21/US07964723B2/abs.jpg.600x600.jpg)
- Patent Title: And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
- Patent Title (中): 专门生产（S）-9-氟-3-甲基-10-（4-甲基-1-哌嗪基）-7-氧代-2,3-二氢-7H-吡啶并[1,2,3 ，de] [1,4]苯并恶嗪-6-羧酸半水合物
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Application No.: US12253553Application Date: 2008-10-17
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Publication No.: US07964723B2Publication Date: 2011-06-21
- Inventor: Zheqing Wang , Lijan Shu , Weifeng Guo , HangChang Zhu , Pingai Yang , Xiaofeng Shen , Chenming Jin
- Applicant: Zheqing Wang , Lijan Shu , Weifeng Guo , HangChang Zhu , Pingai Yang , Xiaofeng Shen , Chenming Jin
- Applicant Address: CN
- Assignee: Apeloa-Kangyu
- Current Assignee: Apeloa-Kangyu
- Current Assignee Address: CN
- Agency: Cantor Colburn LLP
- Main IPC: C07D498/06
- IPC: C07D498/06 ; C07D403/10
![And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate](/abs-image/US/2011/06/21/US07964723B2/abs.jpg.150x150.jpg)
Abstract:
A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de] [1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.
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