A computer-implemented method for determining the health impact of an application based on information obtained from like-profiled computing systems may comprise: 1) obtaining a plurality of computing-system profiles, 2) obtaining system-health-evaluation results for each of the plurality of computing-system profiles, 3) identifying, by analyzing the plurality of computing-system profiles, a first set of like-profiled computing systems, 4) identifying, by analyzing the plurality of computing-system profiles, a second set of like-profiled computing systems that is substantially identical to the first set of like-profiled computing systems but for a first application installed on the second set of like-profiled computing systems, and 5) determining the health impact of the first application by comparing system-health-evaluation results from the first set of like-profiled computing systems with system-health-evaluation results from the second set of like-profiled computing systems. Corresponding systems and computer-readable media are also disclosed.