Invention Grant
- Patent Title: Process for the purification of Ropinirole hydrochloride
- Patent Title (中): 盐酸罗匹尼罗的纯化方法
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Application No.: US12295003Application Date: 2007-03-21
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Publication No.: US07968731B2Publication Date: 2011-06-28
- Inventor: Pandurang Balwant Deshpande , Ashok Prataprai Shanishchara , Trushar Rajanikant Shah , Hitarth Harshendu Acharya , Parven Kumar Luthra
- Applicant: Pandurang Balwant Deshpande , Ashok Prataprai Shanishchara , Trushar Rajanikant Shah , Hitarth Harshendu Acharya , Parven Kumar Luthra
- Applicant Address: IN Vadodara
- Assignee: Alembic Limited
- Current Assignee: Alembic Limited
- Current Assignee Address: IN Vadodara
- Agency: Volpe and Koenig, P.C.
- Priority: IN476/MUM/2006 20060329
- International Application: PCT/IN2007/000116 WO 20070321
- International Announcement: WO2007/110879 WO 20071004
- Main IPC: C07D209/34
- IPC: C07D209/34

Abstract:
An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Public/Granted literature
- US20100249433A1 PROCESS FOR THE PURIFICATION OF ROPINIROLE HYDROCHLORIDE Public/Granted day:2010-09-30
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