Invention Grant
US07968736B2 Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
有权
discodermolide和dictyostatin-1的类似物，其中间体及其合成方法
- Patent Title: Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
- Patent Title (中): discodermolide和dictyostatin-1的类似物，其中间体及其合成方法
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Application No.: US12235720Application Date: 2008-09-23
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Publication No.: US07968736B2Publication Date: 2011-06-28
- Inventor: Dennis P. Curran , Youseung Shin , Nakyen Choy , Billy W Day , Raghavan Balachandran , Charitha Madiraju , Tiffany Turner
- Applicant: Dennis P. Curran , Youseung Shin , Nakyen Choy , Billy W Day , Raghavan Balachandran , Charitha Madiraju , Tiffany Turner
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—of the Commonwelth Systems of Higher Education
- Current Assignee: University of Pittsburgh—of the Commonwelth Systems of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Bartony & Associates, LLC
- Main IPC: C07D313/00
- IPC: C07D313/00
Abstract:
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; Ra, Rb and Rc are independently an alkyl group or an aryl group; Rd is an alkyl group, an aryl group, an alkoxylalkyl group, —RiSiRaRbRc or a benzyl group, wherein Ri is an alkylene group; Re is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRgRh, wherein Rg and Rh are independently H, an alkyl group or an aryl group; R3 is (CH2)n where n is and integer in the range of 0 to 5, —CH2CH(CH3)—, —CH═CH—, —CH═C(CH3)—, or —C≡C—; R4 wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, Rk1, Rk2, Rk3, Rk4 and Rk5 are independently H, CH3, or OR2a, and Rs1, Rs2, Rs3, and Rs4 are independently H or CH3, wherein R2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe; and R5 is H or OR2b, wherein R2b is H, an alkyl group, an aryl group, an aryl group, a benzyl group, a trityl group, —SiRaRbRc, CH2ORd, or CORe.
Public/Granted literature
- US20090036691A1 ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF Public/Granted day:2009-02-05
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