Invention Grant
US07968748B2 Process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest
失效
拆分外消旋混合物和拆分剂和目的对映异构体的非对映异构体复合物的方法
- Patent Title: Process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest
- Patent Title (中): 拆分外消旋混合物和拆分剂和目的对映异构体的非对映异构体复合物的方法
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Application No.: US12278268Application Date: 2007-02-01
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Publication No.: US07968748B2Publication Date: 2011-06-28
- Inventor: Elio Napolitano , Rita Fiaschi , Chiara Bechini , Gabriella Brunetto
- Applicant: Elio Napolitano , Rita Fiaschi , Chiara Bechini , Gabriella Brunetto
- Applicant Address: IT Pisa
- Assignee: Abiogen Pharma S.p.A.
- Current Assignee: Abiogen Pharma S.p.A.
- Current Assignee Address: IT Pisa
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: ITMI2006A0179 20060202
- International Application: PCT/IT2007/000067 WO 20070201
- International Announcement: WO2007/088571 WO 20070809
- Main IPC: C07C237/06
- IPC: C07C237/06 ; C07C211/10
Abstract:
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.
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