Methods, systems and apparatuses for RFID readers forming a reader network are described. In an aspect of the present invention, a plurality of RFID readers are configured to interrogate tags. Furthermore, the readers are configured to communicate with one another. Each of the readers include a ID number which identifies that particular reader within a reader network during communications. Each reader includes a network interface module and an optimization module to receive and process statistical data obtained from other readers in the network. Aspects of the present invention include a ‘primary/secondary’ reader network configuration, as well as a ‘distributed elements’ reader network configuration. A set of operational rules for the environment is indicated, and tag interrogations are optimized according to the rules. Readers may communicate according to a “Listen Before Talk” (LBT) protocol to avoid undesirable interference. Individual readers are capable of dynamically establishing and joining a network, and leaving the network in a self-configured and semi-autonomous or autonomous manner.