Embodiments of the invention are described that provide automated and efficient optimization of camera settings. In certain embodiments of the invention, both focus and exposure settings are determined based on an analysis of compressed images taken of a frame. Based on this analysis, the camera focus and exposure settings are set to provide a preferred image quality of the particular frame. This optimization of the focus and exposure settings is performed at each frame within the multi-frame image source. As a result, each frame image is independently optimized and addresses variations, such as light and surface inconsistencies, across the multi-frame image source.