Policy-based routing system and method for a multi-homed computer. Policy-based routing permits or blocks usage of system level route(s) based on user credentials and/or network application(s) associated with a data transfer. The credentials can include information associated with an application, a user, and the like. Optionally, one or more filter(s) can be configured over classifiable field(s), such as credential(s), information associated with a determined proposed route, to statically permit/block route usage and/or to invoke an inspection module (e.g., custom inspection routine) when the filter condition(s) are met.