An introducer assembly includes a sheath having a sheath proximal end and distal end, and a passage therethrough. The introducer assembly further includes a valve assembly that is sealingly associated with the passage of the sheath. The valve assembly includes a valve having a first seal and a second seal, where the first and second seal optionally have different sealing properties. For example, the first seal and the second seal have different thicknesses, different sealing durometers, or otherwise different sealing features. In another option, the sheath is removable from the instrument disposed therethrough. In yet another option, the valve of the valve assembly further includes a chamber disposed between the first and second seals. The seals are spaced to accommodate devices with multiple flow holes therein.