Invention Grant
US07972601B2 Method of promoting delivery of an antioxidant agent to a cell expression neuroligin
有权
促进抗氧化剂递送至细胞表达神经丝氨酸的方法
- Patent Title: Method of promoting delivery of an antioxidant agent to a cell expression neuroligin
- Patent Title (中): 促进抗氧化剂递送至细胞表达神经丝氨酸的方法
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Application No.: US11596160Application Date: 2005-05-10
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Publication No.: US07972601B2Publication Date: 2011-07-05
- Inventor: Palmer Taylor , Davide Comoletti , Lori Jennings , Robyn Flynn
- Applicant: Palmer Taylor , Davide Comoletti , Lori Jennings , Robyn Flynn
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Gavrilovich Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr.
- International Application: PCT/US2005/017522 WO 20050510
- International Announcement: WO2005/115478 WO 20051208
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/385 ; A01N37/18 ; A01N38/00
Abstract:
Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the endoplasmic reticulum (ER) to reverse incorrect disulfide binding of the protein neuroligin. Also disclosed is a method of targeting the antioxidant to neuroligin by using the calcium binding or other recognition site of neuroligin to bind the antioxidant. The antioxidant can be cysteamine linked to a molecule which binds to a binding site.
Public/Granted literature
- US20070180544A1 Methods and compositions for autism spectrum disorders Public/Granted day:2007-08-02
Information query
