Invention Grant
- Patent Title: Method of manufacturing modified release dosage forms
- Patent Title (中): 制备改性释放剂型的方法
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Application No.: US12391475Application Date: 2009-02-24
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Publication No.: US07972624B2Publication Date: 2011-07-05
- Inventor: Shun-Por Li , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
- Applicant: Shun-Por Li , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
- Agent Laura Donnelly
- Main IPC: A61K9/22
- IPC: A61K9/22 ; A23G3/02

Abstract:
In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
Public/Granted literature
- US20090155372A1 METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS Public/Granted day:2009-06-18
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