Invention Grant
- Patent Title: Beclomethasone dipropionate monohydrate nasal pharmaceutical formulations and methods of using the same
- Patent Title (中): 二丙酸倍氯米松一水合物鼻用药物制剂及其使用方法
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Application No.: US11250256Application Date: 2005-10-14
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Publication No.: US07972627B2Publication Date: 2011-07-05
- Inventor: Imtiaz Chaudry
- Applicant: Imtiaz Chaudry
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Alston & Bird LLP
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/12 ; A61K9/10 ; A61K9/00 ; A61K31/56

Abstract:
Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is beclomethasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is beclomethasone dipropionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.
Public/Granted literature
- US20060039871A1 Nasal pharmaceutical formulations and methods of using the same Public/Granted day:2006-02-23
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