Invention Grant
- Patent Title: DNA encoding a soluble fragment of TRAIL polypeptide
- Patent Title (中): 编码TRAIL多肽可溶性片段的DNA
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Application No.: US12779662Application Date: 2010-05-13
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Publication No.: US07972812B2Publication Date: 2011-07-05
- Inventor: Steven R. Wiley , Raymond G. Goodwin
- Applicant: Steven R. Wiley , Raymond G. Goodwin
- Applicant Address: US CA Thousand Oaks
- Assignee: Immunex Corporation
- Current Assignee: Immunex Corporation
- Current Assignee Address: US CA Thousand Oaks
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C12N15/19 ; C12N15/63 ; C12N15/64
Abstract:
A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
Public/Granted literature
- US20100323399A1 Use of Trail Polypeptides to Treat Cancer Public/Granted day:2010-12-23
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