Invention Grant
US07972836B2 Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline
有权
外消旋4-羟基-1,2,3,4-四氢喹啉的酶学光学拆分方法
- Patent Title: Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline
- Patent Title (中): 外消旋4-羟基-1,2,3,4-四氢喹啉的酶学光学拆分方法
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Application No.: US12083014Application Date: 2006-10-04
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Publication No.: US07972836B2Publication Date: 2011-07-05
- Inventor: Masaki Okamoto , Akira Sakuragi , Muneki Kishida , Yoshikazu Mori
- Applicant: Masaki Okamoto , Akira Sakuragi , Muneki Kishida , Yoshikazu Mori
- Applicant Address: JP Osaka-Shi
- Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee Address: JP Osaka-Shi
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2005-290757 20051004
- International Application: PCT/JP2006/319836 WO 20061004
- International Announcement: WO2007/040238 WO 20070412
- Main IPC: C12P41/00
- IPC: C12P41/00 ; C12P17/18
Abstract:
The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]: [wherein R1 represents a hydrogen atom or a protecting group for amino group.] with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; and if necessary, subjecting the reaction product to solvolysis.
Public/Granted literature
- US20090269821A1 Method for Preparing Optically Active 4-Hydroxy-1,2,3,4-Tetrahydroquinoline Compound Public/Granted day:2009-10-29
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