Invention Grant
- Patent Title: Nuclear factor κB inducing factor
- Patent Title (中): 核因子和kgr B诱导因子
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Application No.: US11354560Application Date: 2006-02-15
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Publication No.: US07972844B2Publication Date: 2011-07-05
- Inventor: June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
- Applicant: June Kaplow , Thomas Haws , Marie Rosier , Patrice Denefle
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Priority: GB0018307.9 20000726
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N15/00 ; C07H21/02 ; C12P21/06
Abstract:
The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
Public/Granted literature
- US20060223771A1 Nuclear factor kappaB inducing factor Public/Granted day:2006-10-05
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