Invention Grant
US07972845B2 Human antibodies against Pseudomonas aeruginosa LPS derived from transgenic xenomouse
有权
针对铜绿假单胞菌LPS的人抗体来自转基因异种子
- Patent Title: Human antibodies against Pseudomonas aeruginosa LPS derived from transgenic xenomouse
- Patent Title (中): 针对铜绿假单胞菌LPS的人抗体来自转基因异种子
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Application No.: US10380092Application Date: 2001-09-07
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Publication No.: US07972845B2Publication Date: 2011-07-05
- Inventor: John R. Schreiber , Kulwant Kamboj
- Applicant: John R. Schreiber , Kulwant Kamboj
- Applicant Address: US OH Cleveland
- Assignee: Case Western Reserve University
- Current Assignee: Case Western Reserve University
- Current Assignee Address: US OH Cleveland
- Agency: Hahn Loeser & Parks, LLP
- Agent John J. Cunniff
- International Application: PCT/US01/28019 WO 20010907
- International Announcement: WO02/20619 WO 20020314
- Main IPC: A61K39/40
- IPC: A61K39/40
Abstract:
The invention described herein provides for human antibodies produced in non-human animals that specifically bind to Pseudomonas aeruginosa Lipopolysaccharide (LPS). The invention further provides methods for making the antibodies in a non-human animal, expression of the antibodies in cell lines including hybridomas and recombinant host cell systems. Also provided are kits and pharmaceutical compositions comprising the antibodies and methods of treating or preventing pseudomonas infection by administering to a patient the pharmaceutical compositions described herein.
Public/Granted literature
- US20040137001A1 Human antibodies against pseudomonas aeruginosa lps derived from transgenic xenomouse Public/Granted day:2004-07-15
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