Invention Grant
US07972850B2 Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
有权
来自灵长类动物胚胎干细胞的神经干细胞，运动神经元和多巴胺神经元的体外分化方法
- Patent Title: Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
- Patent Title (中): 来自灵长类动物胚胎干细胞的神经干细胞，运动神经元和多巴胺神经元的体外分化方法
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Application No.: US11594455Application Date: 2006-11-08
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Publication No.: US07972850B2Publication Date: 2011-07-05
- Inventor: Su-Chun Zhang , Xue-jun Li
- Applicant: Su-Chun Zhang , Xue-jun Li
- Applicant Address: US WI Madison
- Assignee: Wisonsin Alumni Research Foundation
- Current Assignee: Wisonsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady, LLP
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/08 ; A01N63/00 ; A01N65/00
Abstract:
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1−/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
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