Invention Grant
- Patent Title: C-phenyl glycitol compound
- Patent Title (中): C-苯基甘氨醇化合物
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Application No.: US12301463Application Date: 2007-05-18
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Publication No.: US07973012B2Publication Date: 2011-07-05
- Inventor: Hiroyuki Kakinuma , Yohei Kobashi , Yuko Hashimoto , Takahiro Oi , Hitomi Takahashi , Hideaki Amada , Yuki Iwata
- Applicant: Hiroyuki Kakinuma , Yohei Kobashi , Yuko Hashimoto , Takahiro Oi , Hitomi Takahashi , Hideaki Amada , Yuki Iwata
- Applicant Address: JP Tokyo
- Assignee: Taisho Pharmaceutical Co., Ltd
- Current Assignee: Taisho Pharmaceutical Co., Ltd
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2006-139891 20060519; JP2006-200033 20060721
- International Application: PCT/JP2007/060653 WO 20070518
- International Announcement: WO2007/136116 WO 20071129
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H1/00 ; C07H5/04

Abstract:
Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A C-phenyl glycitol compound represented by Formula (I) below or a pharmaceutically acceptable salt thereof or a hydrate thereof wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl group, a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom, R3 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom, Y is a C1-6 alkylene group, —O—(CH2)n- (n is an integer of 1 to 4) or a C2-6 alkenylene group, provided that when Z is —NHC(═NH)NH2 or —NHCON(RB)RC, n is not 1, Z is —CONHRA, —NHC(═NH)NH2 or —NHCON(RB)RC,
Public/Granted literature
- US20100022460A1 C-PHENYL GLYCITOL COMPOUND Public/Granted day:2010-01-28
Information query
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