Invention Grant
US07973013B2 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
有权
用于抗病毒治疗的2'-氟取代的碳 - 核苷类似物
- Patent Title: 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
- Patent Title (中): 用于抗病毒治疗的2'-氟取代的碳 - 核苷类似物
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Application No.: US12885917Application Date: 2010-09-20
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Publication No.: US07973013B2Publication Date: 2011-07-05
- Inventor: Aesop Cho , Choung U. Kim , Samuel E. Metobo , Adrian S. Ray , Jie Xu
- Applicant: Aesop Cho , Choung U. Kim , Samuel E. Metobo , Adrian S. Ray , Jie Xu
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H5/04 ; C07H7/06
Abstract:
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.
Public/Granted literature
- US20110070194A1 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT Public/Granted day:2011-03-24
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