Invention Grant
US07973041B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
有权
取代的环状异羟肟酸盐作为基质金属蛋白酶的抑制剂
- Patent Title: Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
- Patent Title (中): 取代的环状异羟肟酸盐作为基质金属蛋白酶的抑制剂
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Application No.: US12070310Application Date: 2008-02-15
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Publication No.: US07973041B2Publication Date: 2011-07-05
- Inventor: Yun-Long Li , Jincong Zhuo , David M. Burns , Wenqing Yao , Ravi Kumar Jalluri
- Applicant: Yun-Long Li , Jincong Zhuo , David M. Burns , Wenqing Yao , Ravi Kumar Jalluri
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/497
- IPC: A61K31/497

Abstract:
The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
Public/Granted literature
- US20080167288A1 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases Public/Granted day:2008-07-10
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