Invention Grant
US07973143B2 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
有权
鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
- Patent Title: Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
- Patent Title (中): 鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
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Application No.: US12341520Application Date: 2008-12-22
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Publication No.: US07973143B2Publication Date: 2011-07-05
- Inventor: Julie D. Saba , Jianhui Zhou
- Applicant: Julie D. Saba , Jianhui Zhou
- Applicant Address: US CA Oakland
- Assignee: Children's Hospital & Research Center at Oakland
- Current Assignee: Children's Hospital & Research Center at Oakland
- Current Assignee Address: US CA Oakland
- Agency: Seed IP Law Group PLLC
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K16/00 ; G01N33/573
Abstract:
Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
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