Invention Grant
- Patent Title: Process for the preparation of phenolic hydroxy-substituted compounds
- Patent Title (中): 酚羟基取代化合物的制备方法
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Application No.: US11577434Application Date: 2005-12-07
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Publication No.: US07973185B2Publication Date: 2011-07-05
- Inventor: András Vass , József Dudás , László Borbély , Ferenc Haász , Péter Jekkel
- Applicant: András Vass , József Dudás , László Borbély , Ferenc Haász , Péter Jekkel
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Nyrt.
- Current Assignee: Richter Gedeon Nyrt.
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: HU0402530 20041208; HU0501044 20051111
- International Application: PCT/HU2005/000128 WO 20051207
- International Announcement: WO2006/061666 WO 20060615
- Main IPC: C07J1/00
- IPC: C07J1/00

Abstract:
The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae R1 stands for straight chain or branched C1-6 alkyl group; R2, R3 , R4 , R5, and R6 have the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, C1-6 alkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or R2 and R3 together stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or C1-6 alkylcarbonyloxy group in the 17 position.
Public/Granted literature
- US20080039643A1 Process for the Preparation of Phenolic Hydroxy-Substituted Compounds Public/Granted day:2008-02-14
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