A system and method for detection of alpha particles generated by a test material in proximity to a light atomic weight element. The system includes a neutron detector that is configured to detect a rate of generation of neutrons produced by an (alpha, n) reaction between the test material and the light atomic weight element. There is also at least one gamma-ray detector configured to measure a rate of generation of 511 keV gamma rays produced by an annihilation reaction triggered by a positron emission from a daughter product of the light atomic weight element. A comparator is configured to compare the rate of generation of neutrons and the rate of generation of 511 keV gamma rays.