Auto-calibration of the analog circuits occurs when requested by a user and/or the occurrence of an event(s). The user may invoke an auto-calibration on demand through an auto-calibration (ACAL) input to the mixed-signal integrated circuit. An external voltage calibration (VCAL) input may be used for auto-calibration of the mixed-signal integrated circuit to a user-supplied common-mode voltage reference. Auto-calibration of the mixed-signal integrated circuit may also be initiated upon the occurrence of any one or more of the following events: 1) detection of auto-calibration data corruption, e.g., parity checking of auto-calibration data values digitally stored in the mixed-signal integrated circuit; 2) an internal timer that causes a calibration request after a programmable timeout period, 3) change in the internal integrated circuit die temperature as determined by a temperature sensor, and 4) a change in the power supply and/or internal supply voltage(s).