Methods and systems for adaptive cross-layer cross-node optimization in wireless communication systems are provided. Adaptive cross-layer cross-node optimization allows for conventional cross-layer optimization coupled with the ability to adaptively optimize cross-layer interactions across node boundaries. In one aspect, adaptive cross-layer cross-node optimization includes adaptively and dynamically shifting functions/layers among nodes in a network, so that a global network objective is achieved. In another aspect, adaptive cross-layer cross-node optimization includes adaptively and dynamically distributing functions/layers across a network, according to changes and/or events in the network. In a further aspect, adaptive cross-layer cross-node optimization includes dynamically defining or changing individual node functions within a network, so that a global network functionality may emerge.