A memory hub having an integrated non-volatile memory for storing configuration information is provided. The memory hub includes a high-speed interface for receiving memory access requests, a non-volatile memory having memory configuration information stored therein, and a memory controller coupled to the high-speed interface and the non-volatile memory. The memory controller includes registers into which the memory configuration information is loaded and is operable to output memory requests in response to receiving memory access requests from the high-speed interface and in accordance with the memory configuration information loaded in the registers. A method for initializing a memory sub-system is also provided. The method includes loading configuration registers of a plurality of memory hubs with the configuration information provided by a respective one of a plurality of embedded non-volatile memories integrated in the respective memory hub.