According to the method for configuring an information system (1), components (2) are provided for the information system (1) and component-specific error susceptibility data (3) on the individual components (2). For a given system configuration (5), error susceptibility information (7) is determined for the information system (1) in this given system configuration (5) as a function of the component-specific error susceptibility data (3). The error susceptibility information (7) is evaluated with reference to given evaluation criteria (8). In a subsequent step, the information system (1) is configured in the given system configuration (5) if the error susceptibility information (7) satisfies the given evaluation criteria (8). By means of the method, it is achieved that only system configurations are accepted that satisfy requirements specified by the evaluation criteria (8) with respect to the reliability of the information system (1).