A method of detecting disconnect of a patient circuit of a ventilation system, wherein a circuit disconnect is detected with a first sensitivity and a second sensitivity. The circuit disconnect detected with the first sensitivity is performed by detecting a volume loss for a minimum period of time, detecting a peak pressure loss for at least two consecutive breathing cycles or a minimum period of time, and detecting a pressure loss continuing for a predetermined period of time. The circuit disconnect detected with the second sensitivity is performed by detecting a volume loss for a single breathing cycle, detecting a pressure loss for a single breathing cycle, and detecting an increase of compliance. The first sensitivity is lower than the second sensitivity. Preferably, an alarm is activated when the circuit disconnect is detected with the first sensitivity, and subsystems of the ventilation system is informed of the circuit disconnect that has been detected with the second sensitivity.