Invention Grant
- Patent Title: Method or agent for inhibiting the function of efflux pump Pseudomonas aeruginosa
- Patent Title (中): 抑制外排泵铜绿假单胞菌功能的药剂方法
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Application No.: US12161557Application Date: 2007-02-09
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Publication No.: US07985410B2Publication Date: 2011-07-26
- Inventor: Eisaku Yoshihara , Hidatoshi Inoko
- Applicant: Eisaku Yoshihara , Hidatoshi Inoko
- Applicant Address: JP Kanagawa
- Assignee: Tokai University
- Current Assignee: Tokai University
- Current Assignee Address: JP Kanagawa
- Agency: Bozicevic, Field & Francis, LLP
- Agent Carol L. Franis
- Priority: JP2006-033522 20060210
- International Application: PCT/JP2007/000072 WO 20070209
- International Announcement: WO2007/091395 WO 20070816
- Main IPC: A61K39/40
- IPC: A61K39/40
Abstract:
The purpose of the present invention is to provide a method and an agent to efficiently inhibit the function of the drug efflux pump of Pseudomonas aeruginosa. The invention provides a method to inhibit the function of the drug efflux pump of Pseudomonas aeruginosa, comprising modifying any amino acid residue selected from 100th to 109th or 311th to 320th amino acid residues in the amino acid sequence of mature OprM protein. The invention also provides an agent having such inhibitory effect, and a screening method thereof.
Public/Granted literature
- US20090221097A1 METHOD OR AGENT FOR INHIBITING THE FUNCTION OF EFFLUX PUMP OF PSEUDOMONAS AERUGINOSA Public/Granted day:2009-09-03
Information query
