Invention Grant
- Patent Title: Method for predicting responsiveness to TNFα blocking agents
- Patent Title (中): 预测TNFα阻断剂反应性的方法
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Application No.: US12300847Application Date: 2007-05-15
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Publication No.: US07985549B2Publication Date: 2011-07-26
- Inventor: Jean-Philippe Salier , Maryvonne Daveau , Anne-Christine Gauthier-Jauneau , Olivier Vittecoq , Xavier Le Loet , Alain Daragon , Othmane Mejjad , Thierry Lequerre
- Applicant: Jean-Philippe Salier , Maryvonne Daveau , Anne-Christine Gauthier-Jauneau , Olivier Vittecoq , Xavier Le Loet , Alain Daragon , Othmane Mejjad , Thierry Lequerre
- Applicant Address: FR Paris cedex
- Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)
- Current Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)
- Current Assignee Address: FR Paris cedex
- Agency: Occhiuti Rohlicek & Tsao LLP
- Priority: EP06290789 20060516
- International Application: PCT/IB2007/002373 WO 20070515
- International Announcement: WO2007/135568 WO 20071129
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53 ; C12N15/11 ; C12N15/12 ; C07H21/04
Abstract:
The invention provides an in vitro method for predicting whether a patient would be responsive to a treatment with a TNFα blocking agent, which method comprises determining the expression level of eight genes in a biological sample of said patient, wherein said genes are EPS15, HLA-DPB1, AKAP9, RASGRP3, MTCBP-1, PTNP12, MRPL22 and RPS28. The invention further provides a DNA chip for performing such method.
Public/Granted literature
- US20090252740A1 Method for Predicting Responsiveness to TNF Alpha Blocking Agents Public/Granted day:2009-10-08
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