Invention Grant
- Patent Title: Amide derivative or salt thereof
- Patent Title (中): 酰胺衍生物或其盐
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Application No.: US12279221Application Date: 2007-02-07
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Publication No.: US07985764B2Publication Date: 2011-07-26
- Inventor: Hidetaka Kaku , Hiroyoshi Yamada , Daisuke Kaga , Ryushi Seo , Shinobu Akuzawa
- Applicant: Hidetaka Kaku , Hiroyoshi Yamada , Daisuke Kaga , Ryushi Seo , Shinobu Akuzawa
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Fitzpatrick, Cella, Harper & Scinto
- Priority: JPP2006-041827 20060220
- International Application: PCT/JP2007/052109 WO 20070207
- International Announcement: WO2007/097197 WO 20070830
- Main IPC: C07D209/08
- IPC: C07D209/08 ; A61K31/404

Abstract:
It was found that a compound according to the following formula: or a pharmaceutically acceptable salt thereof, has a strong antagonism for both the 5-HT2B and 5-HT7 receptors. In addition, the compound shows good pharmacological action as compared to antagonists selective for only one of these receptors. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).
Public/Granted literature
- US20090062363A1 AMIDE DERIVATIVE OR SALT THEREOF Public/Granted day:2009-03-05
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