Invention Grant
US07985835B2 Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
失效
甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
- Patent Title: Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
- Patent Title (中): 甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
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Application No.: US11598011Application Date: 2006-11-13
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Publication No.: US07985835B2Publication Date: 2011-07-26
- Inventor: Thomas J. Gardella , Henry M. Kronenberg , John T. Potts , Harald Jüppner
- Applicant: Thomas J. Gardella , Henry M. Kronenberg , John T. Potts , Harald Jüppner
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Clark & Elbing LLP
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/10 ; A61K38/22 ; A61K51/00 ; A61K103/10 ; A61P19/08
Abstract:
Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.
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