Invention Grant
US07985858B2 Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
有权
6-α-羟基-N-烷基化阿片剂的制备方法
- Patent Title: Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
- Patent Title (中): 6-α-羟基-N-烷基化阿片剂的制备方法
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Application No.: US12444421Application Date: 2008-05-02
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Publication No.: US07985858B2Publication Date: 2011-07-26
- Inventor: Christopher W. Grote , Peter X. Wang , Tao Jiang , Gary L. Cantrell , Frank W. Moser , Catherine E. Thomasson
- Applicant: Christopher W. Grote , Peter X. Wang , Tao Jiang , Gary L. Cantrell , Frank W. Moser , Catherine E. Thomasson
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt Inc.
- Current Assignee: Mallinckrodt Inc.
- Current Assignee Address: US MO Hazelwood
- International Application: PCT/US2008/062413 WO 20080502
- International Announcement: WO2008/137672 WO 20081113
- Main IPC: C07D489/08
- IPC: C07D489/08 ; C07D489/02
Abstract:
The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
Public/Granted literature
- US20100041888A1 Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates Public/Granted day:2010-02-18
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