Output stage and related method applied to source driver/chip of LCD panel. While performing dot polarization inversion for even/odd channels of LCD panel, n-channel and p-channel MOS transistors of symmetric layout are respectively adopted for alternately transmitting a positive polarization signal of higher swing range and a negative polarization signal of lower swing range from corresponding drivers of asymmetric layout to the even/odd channels, such that a layout area for alternating polarizations can be reduced. Also, the invention directly ties inputs of the output drivers to VDD or VSS so as to turn off the drivers for providing high impedance at the even/odd channels when necessary.