A safety shield incorporating a locking clip to prevent inadvertent sticks or punctures by a needle is provided. The needle can be a needle cannula or other piercing member, disposed in a sliding orientation in the safety shield, such that the needle slides within the locking clip between an aperture at a proximal end of the locking clip and a trigger hole at a distal end of the clip. Upon withdrawal of the needle after use, a binding orientation is triggered when the needle tip is withdrawn from the trigger hole. As further protection to the bi-directional lock afforded by the binding orientation, the needle is provided with a safety stop to prevent movement of the needle tip through the aperture. In other aspects, the safety shield includes a trigger bushing, in which the needle cannula is slidably received, that is sized larger than the aperture.