Invention Grant
- Patent Title: Compositions and methods for detecting cryptococcus neoformans
- Patent Title (中): 用于检测隐球菌新生隐球菌的组合物和方法
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Application No.: US12214317Application Date: 2008-06-18
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Publication No.: US07989186B2Publication Date: 2011-08-02
- Inventor: Melanie Feola , Martin Adelson , Eli Mordechai , John Entwistle
- Applicant: Melanie Feola , Martin Adelson , Eli Mordechai , John Entwistle
- Applicant Address: US NJ Hamilton
- Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee Address: US NJ Hamilton
- Agent Siu K. Lo, JD; Michael T. Barber
- Main IPC: C12P19/34
- IPC: C12P19/34

Abstract:
Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Cryptococcus neoformans. Real-time PCR and detection using florescence resonance energy transfer is disclosed.
Public/Granted literature
- US20090246767A1 Compositions and methods for detecting Cryptococcus neoformans Public/Granted day:2009-10-01
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